The bacterium Deinococcus (formerly Micrococcus) radiodurans and other members of the eubacterial family Deinococaceae are extremely resistant to ionizing radiation and many other agents that damage DNA. Stationary phase D. radiodurans exposed to 1.0‐1.5 Mrad γ‐irradiation sustains >120 DNA double‐strand breaks (dsbs) per chromosome; these dsbs are mended over a period of hours with 100% survival and virtually no mutagenesis. This contrasts with nearly all other organisms in which just a few ionizing radiation induced‐dsbs per chromosome are lethal. In this (...) article we present an hypothesis that resistance of D. radiodurans to ionizing radiation and its ability to mend radiation‐induced dsbs are due to a special form of redundancy wherein chromosomes exist in pairs, linked to each other by thousands of four‐stranded (Holliday) junctions. Thus, a dsb is not a lethal event because the identical undamaged duplex is nearby, providing an accurate repair template. As addressed in this article, much of what is known about D. radiodurans suggests that it is particularly suited for this proposed novel form of DNA repair. (shrink)

In this engaging study, the authors put casuistry into its historical context, tracing the origin of moral reasoning in antiquity, its peak during the sixteenth and early seventeenth century, and its subsequent fall into disrepute from the mid-seventeenth century.

Catholic evolutionists have proposed to reconcile evolutionary anthropogenesis with Catholic doctrine by suggesting that a created soul could be infused into a body produced by evolution from an animal body. Could such an infusion yield not just a Platonic composite but a being with the unity of substance required by a Thomistic philosophy of nature? How could such a soul be the form of the body into which it was infused? This paper suggests that animals seem to have sense-powers with (...) a level of complexity, if not sufficient to underlie the abstraction of concepts in a being that also has a rational soul, then at least nearly so. The burden of proof lies rather on those who think that evolutionary development of such powers is not possible. In its final section, the paper argues that the existence of Eve as a second, and the only additional, initial rational being does not create special problems for the view here articulated. (shrink)

This article argues that the Mondragon cooperatives, a network of worker-owned businesses in the Basque region of Spain, offers a concrete example of Deweyan economy, wherein democracy is part of everyday work-life. It first identifies three central features of Deweyan economy: a) its notion of economic growth is rooted in human growth; b) it is organic and evolutionary, not ideological or utopian; and c) it is empirical and experimental. Second, the article sketches some of the important historical and philosophical influences (...) upon and distinct features of the Mondragon cooperatives, and, third, it indicates how the Mondragon cooperatives manifest each of the three central features of Deweyan economy. The article concludes by suggesting that the Mondragon cooperatives have achieved a previously unknown level of economic democracy and that its recent modifications in response to changing economic conditions, far from being retreats from fundamental principles, as some critics maintain, are evidence of Mondragon’s experimental, non-ideological character. Furthermore, it is an economic model that transcends the stale, false capitalist-socialist dichotomy and thereby helps us to imagine creative solutions to current economic problems. (shrink)

“Buddhisms” captures the challenge inherent in the diverse practices and beliefs of this religion. In this book, grounding the analysis in the bodies of practitioners provides a new opportunity for coherence that reaches across vast expanses of time and space.

The responsible corporate officer doctrine is, as a formal matter, an instance of strict criminal liability: the government need not prove the defendant’s mens rea in order to obtain a conviction, and the defendant may not escape conviction by proving lack of mens rea. Formal strict liability is sometimes consistent with retributive principles, especially when the strict liability pertains to the grading of an offense. But is strict liability consistent with retributive principles when it pertains, not to grading, but to (...) whether the defendant has crossed the threshold from noncriminal to criminal conduct? In this essay, I review the two most plausible arguments supporting an affirmative answer in the context of the RCO doctrine. First, perhaps this doctrine reflects a rule-like form of negligence, akin to a rule that prohibits selling alcohol to a minor. Second, perhaps this doctrine expresses a duty to use extraordinary care to prevent a harm. Neither argument is persuasive. The first argument, although valid in some circumstances, fails to explain and justify the RCO doctrine. The second argument, a duty to use extraordinary care, is also inadequate. If “extraordinary care” simply means a flexibly applied negligence standard that considers the burdens and benefits of taking a precaution, it is problematic in premising criminal liability on ordinary negligence. If instead it refers to a higher duty or standard of care, it has many possible forms, such as requiring only a very slight deviation from a permissible or justifiable standard of conduct, placing a “thumb” on the scale of the Learned Hand test, identifying an epistemic standard more demanding than a reasonable person test, or recognizing a standard that is insensitive to individual capacities. However, some of these variations present a gratuitous or incoherent understanding of “negligence,” and none of them sufficiently explain and justify the RCO doctrine. (shrink)

This chapter contains sections titled: Caffeine: A Brief History of the Buzz Caffeine as a Mental Performance‐Enhancing Drug Caffeine as a Physical Performance‐Enhancing Drug Caffeine as Doping Cheating and Unfairness Unnaturalness Harm.

The opening of the archives for the pontificate of Pius XII makes it possible to see the history of the drafting of the encyclical _Humani generis_, the first document in which the universal magisterium of the Catholic Church addressed the question of evolution. Although its acknowledgment that the question of the evolutionary origin of the human body was, provisionally, theologically open generated no controversy at the drafting commission, the definitiveness of its reservations about monophyletic polygenism generated a disagreement resolved only (...) by Pope Pius. An incident in 1955 reinforces these conclusions about the proper interpretation of the encyclical. (shrink)

One of the largest, oldest, and most interesting challenges in health care is the balancing act in which clinicians have generally uncontroversial duties both to individual patients and to communities. Physicians and nurses must — so we teach them — put patients first, and at the same time recognize that individuals are members of communities. Individuals affect the health of communities, and communities affect the health of individuals. Thus, the moral and professional duties that result are sometimes in conflict.Moreover, the (...) traditional, prosaic clinical encounter is evolving in an environment increasingly shaped by electronic health records, personal health records, pharmacogenomics and vast networks of data collection and storage for public health surveillance, human subjects research, health services evaluation, and comparative effectiveness research. Health information technology is changing everything. It would be perverse otherwise: imagine large amounts of data and information either ignored, missed, or collected and then ignored. (shrink)

For over 2000 years, economics was studied in the West as a branch of ethics, or moral philosophy. Presently, though, few economists and no textbook in economic orthodoxy claim any close connection between economic science and philosophy. However, might the current 'crises' in economics, and in the economics profession have their deep roots in the separation of economics from philosophy and ethics? American pragmatism, among the various contemporary philosophic traditions, lends itself specially to dialogue with economics because of its view (...) of philosophy as an instrument for solving the real, concrete problems of human life, both personal and social. The essays in this volume, drawing heavily on the tradition of pragmatism, suggest that the economic crises of our time might not be merely technical in nature - that is, the result of faulty applications of economic tools by politicians and policy makers, based up conventional economic models - but also due to the faulty philosophical assumptions underlying those models. These essays suggest that the overcoming of our current economic crises requires that economists once again become moral philosophers, or that philosophers once again engage themselves in economic matters. In either case, this volume aims to foster dialogue between the two disciplines and in that way, contribute to the improvement of contemporary economic life. This book is suitable for those who study political economy, economic theory and economic philosophy. (shrink)

capitalist proponents and orthodox Marxists alike tend to agree that capitalism entails a significant break from systems of chattel slavery: both claim that there is a significant, substantive difference between a system that commands and oppresses labor directly and one that commands labor indirectly through the private ownership of capital, although Marxists would deny that the latter is any less oppressive that the former. Apologists for capitalism commonly claim that the rise of that system ended slavery and that the overthrow (...) of slavery by “free labor” is the clearest evidence of capitalism’s moral superiority over other economic systems. Orthodox Marxists, such as Eugene Genovese, concur that slavery in the Americas was “precapitalist,”(45) and that capitalism brought it to an end, although they would maintain more continuities between the two systems than capitalism’s defenders would admit, and deny any moral advantage to “wage slavery” over chattel slavery. Defenders of capitalism are wrong on this matter for several reasons, but what I wish to focus upon in this paper is how a Weberian understanding of capitalism as a “spirit” or ethos, rather than in terms of a set of economic institutions and practices, demonstrates how the Caribbean slave trade was an early manifestation of capitalism rather than its antithesis. (shrink)

Between 1924 and 1937, the Jesuit Curia in Rome repeatedly placed restrictions on what Jesuit priest‐paleontologist Pierre Teilhard de Chardin was allowed to write on those aspects of human origins that, in the view of the Curia, had theological as well as scientific aspects. In 2018, David Grumett and Paul Bentley published an account of the first of those restrictions, together with a previously undiscovered document associated with that restriction. This article corrects a relatively important error in their historical narrative, (...) offers an alternative to their comments about the case, and concludes by embedding the events of 1924–1925 in a slightly larger history of Teilhard's relations with the Jesuit Curia and with the Holy Office. That larger narrative shows that, while Grumett and Bentley's account was mistaken about the involvement of the Holy Office in the case they discuss, it was not wrong about the concerns of that Congregation in questions of human origins. (shrink)

The aim of this paper is to trace how a perverted understanding of the human – of human nature, growth, and well-being – came to form the foundation for classical liberal economic thought and to identify some of the negative consequences of this development. My suggestion is that, in response to the social upheaval of the 16th, 17th, and 18th centuries that would lead to the rise of capitalism and make possible the industrial revolution, moral philosophers applied to humans and (...) to human society mechanistic principles from the highly successful natural sciences in an effort to make sense of a social world that had ceased to make sense. Thus emerged the impoverished view of the human that lies at the foundation of mainstream economic thinking: homo economicus – the human as a rational, utility-optimizing machine, driven by unlimited desires. (shrink)

In Schools of Thought in International Relations, renowned foreign-affairs scholar Kenneth W. Thompson seeks to clarify the study of international relations theory by succinctly addressing salient issues in its intellectual history.

In this informed and comprehensive assessment of current issues in international policies, Kenneth W. Thompson addresses the role that traditions and values play in shaping change and in helping us to understand its implications. He challenges the idea that the enormous changes in contemporary national and international life have rendered the consideration of traditions and values obsolete. Thompson’s purpose is to illuminate the problems we face and to set forth general principles directed toward an informing theory on traditions and (...) values as they affect politics and diplomacy, while at the same time warning of the pitfalls and limitations of theory. In the first section of this book, Thompson draws on classical and Judaeo-Christian traditions in defining the relationship between philosophy, religion, and politics. He then examines the application of abstract values to such political realities as national interest, and goes on to consider the question of moral values in international diplomacy and politics. In a series of case studies, Thompson reflects on human rights, disarmament and arms control, and human survival. Maintaining that the implementation of traditions and values is sometimes uniquely the task of the American presidency, he studies the administrations of four postwar presidents—Dwight D. Eisenhower, John F. Kennedy, Lyndon B. Johnson, and Richard M. Nixon—in the light of the executives’ attitudes toward ethics and politics. Finally, Thompson considers the implications of national decline and the breakdown of international order for the future of the United States. The vast knowledge of international affairs and the literature of politics that Kenneth W. Thompson brings to this timely and reflective books makes it exceptionally readable as well as intellectually challenging. (shrink)

Economist Amartya Sen’s and philosopher Martha Nussbaum’s capabilities approach to economic development enjoys global attention, and there has been considerable interest in connections between it and pragmatism. 1 This paper argues, first, that there are indeed strong, productive affinities between Sen’s and Nussbaum’s understanding of ‘capabilities’ in rethinking how economies are to be developed and measured, on the one hand, and John Dewey’s notion of ‘growth’ and applications of pragmatism to economics, by economists such as Thorstein Veblen, John Commons, and, (...) more recently, Daniel Bromley, to rethink and to reconstruct their discipline, on the other. Second, the paper suggests that Dewey’s notion of ‘growth’ can do much to strengthen and to deepen Sen’s and Nussbaum’s “capabilities approaches” to economics. Third, it suggests that Dewey enriches notions of ‘science’ and ‘democracy’, which are largely underdeveloped in capabilities approaches. (shrink)

This article explores different dimensions of the concept of negligence in the law. The first sections focus on the fundamental distinction between conduct negligence, a conception that dominates tort law; and cognitive negligence, a conception that is much more important in criminal law. The last major section identifies five significant institutional functions served by a legal negligence standard: expressing a legal norm in the form of a standard rather than a rule; personifying fault; empowering the trier of fact to give (...) content to the standard; creating a secondary legal norm parasitic on a primary legal norm; and distinguishing grades of fault. These functions reveal the distinctive significance of negligence, but also disclose numerous problems that the use of such a legal standard can pose. Careful analysis of these different dimensions of negligence clarifies certain misconceptions and has important implications. For example, the question whether "negligence" is an appropriate minimum standard of liability is unanswerable until we identify the type of negligence at issue and its role in norm-definition. Similarly, comparing negligenceto supposedly "more serious" forms of fault, such as recklessness, knowledge, and purpose, is treacherous and sometimes amounts to comparing apples and oranges. A better understanding of the different conceptions of negligence and of the distinctive institutional functions of a legal negligence standard can facilitate the development of more coherent, and more justifiable, fault criteria in criminal law, torts, and other legal domains. (shrink)

from my first courses as an undergraduate in African American studies, I have been concerned about the dynamics by which white and Black1 people discuss race. For one, I was troubled in my undergraduate African American studies courses by the ease with which white students would insert themselves into conversations where, it seemed to me, they simply did not belong, for example, conversations concerning visions for the future of the Black community and strategies for achieving such visions. Shannon Sullivan speaks (...) of this phenomenon, accurately I believe, as “ontological expansiveness”: one central feature of privilege is a sense of entitlement to enter every room without first considering whether or not one is .. (shrink)

In 300 BCE, the tutor of the heir-apparent to the Chu throne was laid to rest in a tomb at Jingmen, Hubei province in central China. A corpus of bamboo-strip texts that recorded the philosophical teachings of an era was buried with him. The tomb was sealed, and China quickly became the theater of the Qin conquest, an event that proved to be one of the most significant in ancient history. For over two millennia, the texts were forgotten. But in (...) October 1993, they were unearthed. The discovery of the Guodian texts, together with other recently discovered Warring States manuscripts, has revolutionized the study of early Chinese intellectual history. Kenneth Holloway argues that the Guodian corpus puts forth a political philosophy based on the harmonious interconnection of individuals engaged in moral self-cultivation. This unique worldview, says Holloway, cannot meaningfully be categorized as "Confucian" or "Daoist," because it shares important concepts and vocabulary with a number of different textual traditions that have anachronistically been characterized as competing or incompatible "schools" of thought. He finds that within the Guodian corpus familiar philosophical concepts and texts are applied in distinctive ways, presenting a worldview that is quite different from the received textual traditions. In the corpus, the most important function of government is to assist in the harmonization of state and family relations. It sees the relationship between these two entities - the family and the collection of families that ultimately constitute the state - as being inherently conflicting social groupings. The texts posit an interesting solution: State and family disharmony can be overcome by developing a hybrid government that employs both meritocratic and aristocratic methods. Without knowledge of the emphasis on hybridization found in the Guodian texts, however, scholars were unable to understand the interrelationships between these two methods of government. This new understanding illuminates central issues of government, religion, and philosophy in early China that were overlooked in received texts. As part of the contribution to our understanding of this particular body of texts, Holloway proposes a methodology for assessing a corpus of texts without relying on assumptions and definitions that derive from two thousand years of scholarship. The Guodian corpus, and Holloway's analysis of it, are now absolutely indispensable to any student or scholar of ancient Chinese intellectual history. (shrink)

despite the fact that pragmatism spawned a whole school of economics, namely, Institutionalism, relatively little work has been done by pragmatists in philosophy to apply pragmatism to contemporary economic issues or to the rethinking of economic theory, which seems to be unraveling in the current state of economic crisis. There are notable exceptions, of course, and I mention here especially the work of Judith Green, in applying pragmatism in the furtherance of economic democracy; Larry Hickman’s fine essays in deepening our (...) understanding of the pragmatist sources of Institutionalist thinkers such as Thorstein Veblen ; and Ron Nahser, a marketing executive who also wrote and published.. (shrink)

Francisco Ayala and others have argued that recent genetic evidence shows that the origins of the human race cannot be monogenetic, as the Church hastraditionally taught. This paper replies to that objection, developing a distinction between biological and theological species first proposed by Andrew Alexanderin 1964.

The purpose of this article is to contribute to a more robust theory of leadership that shifts the frame of reference from leadership as exclusively facilitated through a single inspired leader to one that includes the view of leadership as an emergent and complex social phenomenon. The article begins with a review of the leader-centric approaches that dominated much of twentieth century leadership studies then moves on to present contemporary critiques of leader-centric approaches leading to an alternative perspective of leadership (...) as an emergent and complex social phenomenon. Viewing leadership as an emergent and complex social phenomenon changes our attitude regarding the roles that leaders and others play in the creation of leadership. A central theme of this article is the impact that the concept of emergence has on leadership theory. In response to this changing attitude, the article then moves to return to and reassess the ontological, epistemological and ethical grounds of leadership and concludes that there is an underlying philosophy that supports viewing leadership as an emergent social phenomenon and further suggests that recent work in virtue epistemology along with Calvin Schrag’s theory of communicative praxis and transversal rationality, can facilitate a better understanding of leadership as an emergent social phenomenon. (shrink)

Let me begin by repeating my remarks at the close of the annual Business Meeting of the Society for the Advancement of American Philosophy, March 17, 2012 :"We call ourselves the Society for the Advancement of American Philosophy, but one of the hopes of at least Josiah Royce and John Dewey was that great societies might eventually grow into great communities. So I am deeply honored today to assume the position of SAAP's new President because it is an honor that (...) comes not merely from a society of professional colleagues but from a community of friends who have nurtured and supported me for thirty-seven years, both professionally and personally. Initially I came to SAAP in order to share common philosophical .. (shrink)

Focuses on the theory and practice of presidentialism and constitutionalism.

Max Scheler seems to present two distinct approaches to philosophy of culture. In the early period of his Formalismus in der Ethik und die materiale Wertethik and “Ordo Amoris,” he describes cultures as being defined by their distinct order of value preferencings. In his later period of his “Probleme einer Soziologie des Wissens,” however, Scheler explains the dynamics of culture in terms of the interaction of what he calls “real” and “ideal sociological factors,” rooted in various drives and spirit, respectively. (...) These approaches are fully compatible and complementary, the former describing culture’s vertical structure and the latter, its horizontal structure. Together these two approaches offer a comprehensive philosophy of culture, deserving greater attention. (shrink)